The present disclosure relates to a to a method for treating peripheral neuropathy including diabetic neuropathy. It consists of comprehensive set of pain management medications such as sodium channel blockers, N-methyl-D-aspartate (NMDA) receptor antiagonists, α-2 adrenergic receptor agonists, anti-inflammatory drugs, calcium channel blockers, other classes of medications or their mixtures. The medical compound can be encapsulated in PLGA micro-particles for controlled, sustained release over 2-8 weeks. Once a doctor prescribes a set of pain management medications, the prescribed medication(s) can be administered individually or as their mixtures by a commercial painless or user-friendly micro-needle patch or injection device.
