ADAM SORENSON,ARUNPRASAD SIVARAMAN,GREGORY T. FIELDSON,JEFFREY E. CORTOPASSI,TYLER D. SIMMONS
申请号：
BR112015015738
公开号：
BR112015015738A2
申请日:
2013.12.18
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract transdermal dosage form for low-melting point active agent a drug-containing patch allows transdermal administration of a drug. the patch features a hydrophobic reservoir containing the drug, where the reservoir has a first surface and a second surface. a drug-impermeable backing overlies the first surface of the reservoir. a release sheet may overlie the second surface of the reservoir. the hydrophobic reservoir contains a drug and a hydrophobic matrix, where the hydrophobic matrix includes a hydrophobic filler in an amount which is effective to adsorb said drug； and a mixture of polyisobutylene and mineral oil. the hydrophobic matrix may contain colloidal hydrophobic silica as the hydrophobic filler. the hydrophobic reservoir layer may serve as a skin-contacting adhesive layer. alternatively, the release-controlling adhesive layer may serve as the skin-contacting adhesive layer. the release-controlling adhesive layer may contain hydrophobic colloidal silica and a mixture of polyisobutylene and mineral oil. __________________________________________________________ patent summary: "transdermal dosage form for low melting active agent". The invention relates to a drug-containing patch that allows transdermal administration of a drug. The patch is characterized by a hydrophobic drug-containing reservoir, wherein the reservoir has a first surface and a second surface. a drug impermeable backing layer overlaps the first surface of the reservoir. A release sheet may overlap the second surface of the reservoir. the hydrophobic reservoir contains a drug and a hydrophobic matrix, wherein the hydrophobic matrix includes a hydrophobic charge in an amount that is effective for adsorbing said drug； and a mixture of polyisobutylene and mineral oil. The hydrophobic matrix may contain hydrophobic colloidal silica as the hydrophobic filler. The hydrophobic reservoir layer can serve as an adhesive skin contact layer. alternatively, a release control adhesive layer may serv
