The present invention presents an apparatus and methods to generate and deliver circumferential mechanical vibrations to a hypodermic needle penetration site of a human body to reduce pain of needle prick by activating inhibitory neuronal mechanisms for pain perception. The apparatus comprises a detachably disposable proximal end that contacts with a tissue of a recipient and encircles a needle penetration site, a distal end that is configured as a conduit for electric power to the apparatus and a longitudinally tubular handle assembly that is connected to both proximal and distal ends and that houses a vibration assembly and a control and power assembly. The vibration assembly generates and delivers resonant vibrations to the recipient through the proximal end. A needle penetrates the recipients tissue circumferentially surrounded by vibrations transmitted by the proximal end.
