NOVOTNY, JAMES,LONBERG, NILS,HEDVAT, CYRUS,CLYNES, RAPHAEL,LOCKE, DARREN,COGSWELL, JOHN P.,JACKSON, JEFFREY,HARBISON, CHRISTOPHER,EDWARDS, ROBIN
申请号：
CA3060984
公开号：
CA3060984A1
申请日:
2018.05.30
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention provides a method of treating a tumor in a human patientcomprising (i) identifying a patient as havinga LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathwayinhibitor, a combination of a PD1 pathway inhibitor andan immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1pathway inhibitor, or an anti-CTLA4 antibody. Insome embodiments, the method further comprises identifying the patient ashaving a LAG-3 positive PD-L1 positive tumor. In someembodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1pathway inhibitor is an anti-PD-1 antibody. The methodsof the invention can improve response rates to treatment with a PD-1 pathwayinhibitor, a combination of a PD1 pathway inhibitor andan immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.
