Systems/methods for delivery and control of medications for patient use and, more particularly, to dispenser-based systems that facilitate access to and use of individually packaged sets of medications (e.g., pills, tablets and the like), and associated control functionalities that monitor and communicate the status/inventory of medications associated with the dispenser-based system, are provided. Systems/methods that include indicia associated with the packaged sets of medications and for “reading” the indicia to monitor or determine the status or position of the packaged set of medications are also provided.