1,3,4-oxadiazole sulfamide derivative compound as histone deacetylase 6 inhibitor and pharmaceutical composition containing the same (1,3,4-Oxadiazole Sulfuride Derivative Compounds as Histone Deacetylase 6 Inhibitor) , And the Pharmaceutical Composition Comprising the same)
The present invention relates to a novel compound having histone deacetylase 6 (HDAC6) inhibitory activity, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, its use in the manufacture of a medicament for treatment, The present invention relates to a pharmaceutical composition containing the same, a treatment method using the composition, and a production method thereof. The novel compound according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof has a histone deacetylase 6 (HDAC6) inhibitory activity, and is an infectious disease, neoplasm. Endocrine, nutritional and metabolic diseases, mental and behavioral disorders, neurological diseases, eye and appendage diseases, cardiovascular diseases, respiratory diseases, gastrointestinal diseases, skin and subcutaneous tissue diseases, musculoskeletal and connective tissue diseases, Or it is effective in the prevention or treatment of diseases associated with HDAC6 activity including congenital malformations, deformations and chromosomal abnormalities. [Selection figure] None本発明は、ヒストン脱アセチル化酵素６（Ｈｉｓｔｏｎｅ ｄｅａｃｅｔｙｌａｓｅ６、ＨＤＡＣ６）阻害活性を有する新規化合物、その光学異性体、又はその薬剤学的に許容可能な塩、治療のための薬剤の製造におけるその用途、これを含有する薬剤組成物と前記組成物を用いた治療方法、及びその製造方法に関するものである。本発明による新規化合物、その光学異性体、又はその薬剤学的に許容可能な塩は、ヒストン脱アセチル化酵素６（Ｈｉｓｔｏｎｅ ｄｅａｃｅｔｙｌａｓｅ６、ＨＤＡＣ６）阻害活性を有し、感染性疾患、新生物（ｎｅｏｐｌａｓｍ）、内分泌、栄養及び代謝疾患、精神及び行動障害、神経疾患、眼及び付属器疾患、循環器疾患、呼吸器疾患、消化器疾患、皮膚及び皮下組織の疾患、筋骨格系及び結合組織の疾患、又は先天奇形、変形及び染色体異常を含むＨＤＡＣ６活性と関連する疾患の予防又は治療に有効である。【選択図】なし
