RAJESH Z MUJORIYA,DINESH S WANJARI,M D KSHIRSAGAR,D R MUNDHADA,A V CHANDEWARE
申请号：
IN201721047450
公开号：
IN201721047450A
申请日:
2017.12.31
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
In the present Invention it has been demonstrated that the selection of an appropriate delivery system is a critical issue in the development of nasal powder formulations. Incorporation of drug in a powder formulation based on DDWM/C 974P 95/5 and SD 25/75 using the spray drying Technique resulted in similar pharmacological effect in healthy volunteers as the commercial Nesivine® spray (0.05 % w/v). This Invention will focus on powder formulations as carriers for the nasal delivery of peptides, aiming to improve the nasal bioavailability of the drug by enhancing the residence time of the drug in the nasal cavity due to the incorporation of viscosity-enhancing excipients in the formulation.
