ELLSWORTH, Jeff Lynn,BOLEN, Joseph Beene,GREGOIRE, Francine M.,GUILD, Justin
申请号：
WO2016US26703
公开号：
WO2016164762(A1)
申请日:
2016.04.08
申请国别(地区):
世界知识产权组织国际局
年份:
2016
代理人:
摘要：
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding low density lipoprotein receptor comprising least one amino acid mutation in the EGF-A domain and at least one or a single amino acid mutation in the intracellular domain.
