The invention relates to a novel mouse repeller including a cavity defined by a shell and a base, and a power rectification and supply part, an ultrasonic output module and a negative ion generator which are located in the cavity, wherein the power rectification and supply part supplies power to the ultrasonic output module and the negative ion generator, the ultrasonic output module includes an ultrasonic transducer protruding out of the shell, and the negative iron generator includes a discharge electrode plate which is a detachable and cleanable electrode plate. The novel mouse repeller is of an integrated structure and has a remarkable mouse repelling effect; meanwhile, the adopted detachable and cleanable electrode plate is high in power and can be reused after being detached and cleaned, so that a powerful negative ion emitting effect is maintained, and the use cost is obviously reduced.