NARKUNAN, KESAVARAM,CHEN, XINGHAI,KOCHAT, HARRY,HAUSHEER, FREDERICK
申请号：
CA2700904
公开号：
CA2700904C
申请日:
2007.10.16
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
A camptothecin analog for use in the treatment of cancer, said analog havingthestructural formula:(see above formula)wherein R1 and R2 are selected from the group consisting of: R1 is methoxy andR2 ishydrogen； R1 is methoxymethoxy and R2 is hydrogen； R1 is 3'-hydroxypropoxy andR2is hydrogen； R1 is 2'-methoxyethoxy and R2 is hydrogen； R1 is isopropoxy andR2 ishydrogen； R1 is ethoxy and R2 is hydroxyl； R1 is amidomethoxy and R2 ishydroxyl； R1is dimethylcarbamoyloxy and R2 is hydrogen； R1 is ethoxycarbonylmethoxy and R2ishydrogen； R1 is amidomethyloxy and R2 is hydrogen； R1 is carboxymethyloxy andR2 ishydrogen； R1 is 4-morpholinecarbonyloxy and R2 is hydrogen； R1 isdimethylthiocarbamoyloxy and R2 is hydrogen； R1 is ethoxy and R2 is hydrogen；andR1 is cyanomethoxy and R2 is hydrogen； or a pharmaceutically-acceptable saltthereof.
