USE OF PURINE DERIVATIVES FOR THE PRODUCTION OF MEDICAMENTS FOR THE TREATMENT OF MUCOVISCIDOSIS AND DISEASES RELATED TO PROTEIN ADDRESSING ERRORS IN CELLS
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE DE POITIERS
发明人:
BECQ, FREDERIC,MEIJER, LAURENT
申请号：
CA2584195
公开号：
CA2584195C
申请日:
2005.10.14
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The subject of the invention is the use of purine derivatives for the manufacture of medicaments for the treatment of cystic fibrosis and diseases linked to a lack of addressing of proteins in cells, these derivatives corresponding to formula (I): in which, R2, R6 and R9, which are identical to or different from each other, represent a halogen atom, a radical R-NH-, R-NH-NH-, NH2-R'-NH- or R-NH- R'-NH-, wherein R represents a saturated or unsaturated straight or branched chain alkyl radical, an aryl or cycloalkyl radical, or a heterocycle, and R 'a saturated or unsaturated straight or branched chain alkylene group, or an arylene or cycloalkylene group, R and R 'each containing from 1 to 8 carbon atoms, and being substituted, where appropriate, with one or more -OH, halogen, amino or alkyl groups, - R2 may also represent a heterocycle carrying, where appropriate, a saturated straight or branched chain alkyl radical or unsaturated group, an aryl or cycloaryl group, or a heterocycle, optionally substituted by one or more -OH, halogen, amino or alkyl groups, - R 9 may also represent a saturated or unsaturated straight or branched chain alkyl radical, a aryl or cycloalkyl radical, - R2 and R9 may additionally represent a hydrogen atom, with the exception of 2- (2-hydroxyethylamino) -6-benzylamino-9-methylpurine.L'invention a pour objet l'utilisation de dérivés de purines pour fabriquerdes médicaments pour le traitement de la mucoviscidose et de maladies liées àun défaut d'adressage des protéines dans les cellules, ces dérivés répondant àla formule (I): dans laquelle, - R2, R6 et R9, identiques ou différents lesuns des autres, représentent un atome d'halogène, un radical R-NH-, R-NH-NH-,NH2-R'-NH- ou R-NH-R'-NH-, dans lequel R représente un radical alkyle à chaînedroite ou ramifiée, saturé ou insaturé, un radical aryle ou cycloalkyle, ou unhétérocycle, et R' un groupe alcoylène à chaîne droite ou ramifiée, saturé ouinsaturé, ou un groupe arylène ou c
