Da Volterra； Assistance Publique - Hopitaux de Paris e Universite Paris Diderot - Paris 7
发明人:
Antoine Andremont,François Lescure,Jean de Gunzburg
申请号：
BRPI1009823
公开号：
BRPI1009823A2
申请日:
2010.03.12
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
Oral drug delivery formulations which specifically administer antibacterial agents to the ileum, caecum, and/or the colon, without significant administration elsewhere in the gastrointestinal tract, are disclosed. The formulations include, as actives, a combination of a macrolide or aminoglysoside, or quinolone antibacterial and an anti-Gram-negative lipopeptide (polymyxin) antibacterial agent or other peptide antibacterials effective against Gram-negative bacteria. The formulations can be used to treat infections or unwanted colonization in the colon, and to provide effective decontamination of the colonic flora from unwanted or potentially pathogenic bacteria.
