The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.本發明提供特異性結合至LAG-3(例如人類LAG-3)且拮抗LAG-3功能之抗體。亦提供包含該等抗體之醫藥組成物、編碼該等抗體之核酸、用於製備該等抗體之表現載體及宿主細胞,以及使用該等抗體治療受試者之方法。