The present invention relates to processes for the preparation of an endothelial receptor antagonist. The present invention particularly relates to synthesis of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy) -2-(2-pyrimidinyl)-4-pyrimidinyl] benzene sulfonamide (bosentan).La presente invención se refiere procesos para la preparación de un antagonista de receptor endotelial. La presente invención se refiere particularmente a la síntesis de 4-ter-butil-N-[6-(2-hidro xietoxi)-5-(2-metoxifenoxi)-2-(2-pirimidinil)-4-pirimidinil] bencenosulfonamida (bosentan).
