J. Jeffry Howbert,Venkat Reddy Kusukuntla,Alexander Tretyakov,Nathan Nielsen,Pavel Krasik,Ji-Long Jiang,Hong Woon Yang
申请号：
US12614048
公开号：
US08314090B2
申请日:
2009.11.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.
