Methods are provided for treating or preventing human immunodeficiency virus-1 (HIV-1) or human immunodeficiency virus-2 (HIV-2) in a virologically suppressed patient in need thereof comprising switching the patient from an antiretroviral treatment regimen comprising at least three antiretroviral agents to a treatment regimen comprising only two antiretroviral agents. In one aspect the two treatment regimen consists of dolutegravir, rilpivirine and at least one pharmaceutically acceptable excipient, diluent or carrier. In another aspect of the invention, there is provided a multilayer tablet comprising dolutegravir or a pharmaceutically acceptable salt thereof and rilpivirine or a pharmaceutically acceptable salt thereof.本發明提供用於在有需要之病毒學上受壓制患者體內治療或預防人類免疫缺乏病毒-1(HIV-1)或人類免疫缺乏病毒-2(HIV-2)的方法，包含將該患者從包含至少三種抗逆轉錄病毒劑的抗逆轉錄病毒治療方案切換成僅包含兩種抗逆轉錄病毒劑的治療方案。在一個態樣中，二治療方案由度魯特韋、利匹韋林以及至少一種醫藥上可接受之賦形劑、稀釋劑或載劑組成。在本發明的另一個態樣中，提供一種多層錠劑，其包含度魯特韋或其醫藥上可接受之鹽以及利匹韋林或其醫藥上可接受之鹽。
