The invention provides a mouse with ultraviolet light transmission and sterilization, which comprises a mouse, a plurality of UV LED lights and a control unit.The mouse is provided with a transparent shell and an inner shell, the transparent shell is covered and formed on the top surface of the inner shell, and there is a holding space between the transparent shell and the inner shell; a plurality of UV LED lamps are arranged on the holding space on the top surface of the inner shell to generate ultraviolet (UV) light and illuminate and penetrate the transparent shell; and the control unit is used to control each UV LED lights start and turn off, so as to achieve the sterilization effect of UV light on the whole mouse.本創作提供一種紫外線透光殺菌之滑鼠,其包括:一滑鼠、複數UV LED燈及一控制單元。該滑鼠係具有一透明外殼及一內殼,而該透明外殼係包覆成型於該內殼之頂面,且於該透明外殼及該內殼間係有一容置空間;複數UV LED燈係組設於該內殼頂面之容置空間,用以產生紫外線(UV)光並照射、穿透該透明外殼;而該控制單元係用以控制各該UV LED燈之啟動及關閉,進而達到定時藉由紫外光線對整體滑鼠之殺菌效果。