Stephen Williams;Francis Joseph Carr;Stephen D. Gillies
发明人:
Francis Joseph Carr,Stephen Williams,Stephen D. Gillies
申请号：
US13432671
公开号：
US20120183545A1
申请日:
2012.03.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A method of treating an autoimmune disease comprising administering to a patient a therapeutically effective amount of a CD20-binding polypeptide composition comprising a combination of a modified heavy chain variable region polypeptide and a modified light chain variable region polypeptide. The combination can be (a) a modified 2B8 antibody heavy chain variable region polypeptide of SEQ ID NO: 48； and a modified 2B8 antibody light chain variable region polypeptide of SEQ ID NO: 49； or (b) a modified Leu16 antibody heavy chain variable region polypeptide of SEQ ID NO: 50； and a modified Leu16 antibody light chain variable region polypeptide of SEQ ID NO: 51.
