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BIODEGRADABLE COMPOUND, LIPID PARTICLES, COMPOSITION AND KIT COMPRISING LIPID PARTICLES
专利权人:
KABUSHIKI KAISHA TOSHIBA
发明人:
Mitsuko ISHIHARA,Eiichi AKAHOSHI,Katsuyuki NAITO
申请号:
US16567895
公开号:
US20200000723A1
申请日:
2019.09.11
申请国别(地区):
US
年份:
2020
代理人:
摘要:
[Problem]To provide a biodegradable compound having a structure decomposed in a cell, lipid particles containing the compound, and a pharmaceutical composition comprising the lipid particles.[Solution]The compound of the embodiment is represented by the formula (1): P—;[X—;R—;Y—;R′;-Q]2 (1). In the formula,P is an alkyleneoxy having an ether bond,X is a divalent linking group having a tertiary amine structure,R is a divalent linking group,R′; is a single bond or a C1 to C6 alkylene, andQ is a liposoluble vitamin residue, a sterol residue, or a C12 to C22 aliphatic hydrocarbon group. The structure of the compound contains at least one biodegradable group. From the compound in combination with other lipids such as a lipid capable of reducing aggregation, lipid particles can be formed. Further, the compound can be used for a pharmaceutical composition to deliver an activator into cells.
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