#$%^&*AU2011201422B220120209.pdf#####ABSTRACT A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In 5 one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided. GM2612962_11/15 FIGURE 1 1300 1200 1100 U er Lini f Normal Range -- -- -- ----------------- --- - -- -- -- -- -1000 900 a 800 C 700 0 C 600 500 400.2 400 E 300 --- - - - - - - - - - - - - - - - - - - - - - - L- erL- i of N-rnaIRang E5 00 --- - - - - - - - - - - - - - - - - - - - - - Low er Linit of Norm l FRane M 200100 0 72 76 80 84 88 92 96 100 104 108 112 116 120 124 128 132 136 140 144 Time (hr)
