Disclosed herein are methods and compositions for treating or preventing Porcine reproductive and respiratory syndrome (PRRS) infection in a subject. Described herein are compositions comprising an immunogenic porcine reproductive and respiratory syndrome virus (PRRSV) antigen and a nanoparticle. The compositions, immunogenic compositions and vaccines described herein can further comprise one or more adjuvants. The adjuvant can be any composition, pharmacological or immunological agent that modifies the effect of other agents, such as the antigens described herein. In some embodiments, the compositions, immunogenic compositions and vaccines described herein can further comprise both Mycobacterium tuberculosis whole cell lysate, Mycobacterium smegmatis whole cell lysate, and Mycobacterium vaccae whole cell lysate.
