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COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASE COMPRISING MESENCHYMAL STEM CELL TREATED STAT3 INHIBITOR
专利权人:
가톨릭대학교 산학협력단;THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION;CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATIONFOUNDATION
发明人:
CHO, MI LA,조미라,PARK, SUNG HWAN,박성환,YANG, CHUL WOO,양철우,PARK, MIN JUNG,박민정,YOUN, DEOK KYU,윤덕규,KIM, SEOK JUNG,김석중,LEE, SEON YEONG,이선영,LEE, EUN JUNG,이은정,CHO, MI LAKR,PARK, SUNG HWANKR,YANG, CHUL WOOKR,PARK, MIN JUNGKR,YOUN, DEOK KYUKR,KIM, SEOK JUNGKR,LEE, SEON YEONGKR,LEE, EUN JUNGKR
申请号:
KR1020140144100
公开号:
KR1020150144679A
申请日:
2014.10.23
申请国别(地区):
KR
年份:
2015
代理人:
摘要:
The present invention relates to a composition containing a mesenchymal stem cell treated with a STAT3 inhibitor as an active ingredient for preventing or treating immune diseases. According to the present invention, the mesenchymal stem cell treated with a STAT3 inhibitor: can effectively control expression and generation of inflammatory cytokine and inflammation causing factors in a mesenchymal stem cell; has an effect for inhibiting a T cell from being differentiated into a cytotoxic Th17 cell and a cytotoxic Th1 cell if co-cultured with an undifferentiated T cell under an etiology condition; inhibits a function of an immune cell which is abnormally activated; and has an excellent effect of promoting differentiation and activity of the immunoregulatory T cell (Treg), which inhibits a function of an abnormally activated immune cell and controls inflammation reaction. Therefore, the mesenchymal stem cell treated with a STAT3 inhibitor can be used for a cell treatment agent composition which can prevent or treat immune diseases such as autoimmune diseases, inflammatory diseases, and transplant rejection disorders which are caused by abnormality of regulation of various kinds of immune reaction.본 발명은 STAT3 억제제가 처리된 간엽줄기세포를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물에 관한 것이다. 본 발명에 따른 STAT3 억제제가 처리된 간엽줄기세포는 간엽줄기세포에서의 염증성 사이토카인 및 염증 유발인자의 발현과 생성을 효과적으로 억제할 수 있고, 병인조건 하에서 미분화 T 세포와 공조 배양할 경우, T 세포의 세포 독성 Th17 및 Th1 세포로의 분화를 억제하는 효과가 있으며, 비정상적으로 활성화된 면역세포의 기능을 억제하고 염증 반응을 제어하는 특성을 갖는 면역조절 T 세포(Treg)의 분화 및 활성을 증진시키는 효과가 우수한 특징이 있다. 따라서 STAT3 억제제가 처리된 간엽줄기세포는 각종 면역반응의 조절 이상으로 유발되는 자가면역질환, 염증성질환 및 이식거부질환과 같은 면역질환을 예방 또는 치료할 수 있는 세포치료제 조성물로 사용할 수 있는 효과가 있다.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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