An agent increasing effectiveness of DNA vaccine directed against a virus, DNA plasmid preparation, DNA vaccine, method for obtaining modified expressive vector and the application of nucleotide sequence recognized by the agent NF kappa B.
The invention is related to a factor increasing efficiency of a DNA vaccine aimed against a virus, a plasmid DNA preparation, a DNA vaccine, a method of obtaining a modified 3NFKB expression vector and use of a nucleotide sequence recognised by NFKB. More particularly, the provided solution is related to use of a DNA sequence recognised by the NF kappa B nuclear transcription factor (NFKB,nuclear factor kappa B) in a vaccine in order to ensure effective vaccine plasmid transport into the nucleus and to enhance transcription levels of the introduced gene-coding a selected antigen.
