Provided are: an antibody which specifically binds to an ALK2 protein and has an activity of inhibiting BMP signal transduction mediated by ALK2； a method for producing the antibody； and a pharmaceutical composition containing the antibody for treating and/or preventing heterotopic ossification and/or osteodystrophy, anemia, or diffuse intrinsic pontine glioma (DIPG).此申請案係提供一種與ALK2蛋白質專一性結合，且具有經由ALK2的BMP訊息傳遞之抑制活性的抗體、該抗體之生產方法、以及含有該抗體的異位性骨化及/或骨發育不全、貧血、或瀰漫型內因性橋腦神經膠細胞瘤(diffuse intrinsic pontine glioma，DIPG)之治療及/或預防用醫藥組成物。
