1- [4-bromo-5- [1-ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1 for cancer treatment associated with genetic abnormalities of platelet derived growth factor receptor alpha Use of, 6-naphthyridin-3-yl] -2-fluorophenyl] -3-phenylurea and analogs
The present disclosure provides 1- [4-bromo-5- [1-ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl] in cancer treatment. 2-fluorophenyl] -3-phenylurea or 1- (5- (7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)- And to 4-bromo-2-fluorophenyl) -3-phenylurea. Specifically, the present disclosure relates to methods of inhibiting PDGFR kinase and lung adenocarcinoma, squamous cell lung cancer, glioblastoma, juvenile glioma, astrocytoma, sarcoma, gastrointestinal stromal tumor, malignant peripheral neuronal sarcoma, endothelial sarcoma, hypereosinophilic syndrome, idiopathic A method for treating cancer and disorders associated with inhibition of PDGFR kinase, including hypereosinophilic syndrome, chronic eosinophil leukemia, eosinophilia associated acute myeloid leukemia or lymphoblastic T-cell lymphoma.본 개시는 암 치료에서 1-[4-브로모-5-[1-에틸-7-(메틸아미노)-2-옥소-1,2-다이히드로-1,6-나프티리딘-3-일]-2-플루오로페닐]-3-페닐우레아 또는 1-(5-(7-아미노-1-에틸-2-옥소-1,2-다이히드로-1,6-나프티리딘-3-일)-4-브로모-2-플루오로페닐)-3-페닐우레아를 사용하는 것에 관한 것이다. 구체적으로, 본 개시는 PDGFR 키나아제를 억제하는 방법 및 폐선암, 편평 세포 폐암, 교모세포종, 소아 신경교종, 성상세포종, 육종, 위장관 간질 종양, 악성 말초신경 외피 육종, 내피 육종, 과호산구 증후군, 특발성 과호산구 증후군, 만성 호산구 백혈병, 호산구 증가증 연관 급성 골수성 백혈병 또는 림프아구성 T-세포 림프종을 포함하여 PDGFR 키나아제의 억제와 연관된 암과 장애를 치료하는 방법에 관한 것이다.
