Systems and methods for ligation of a blood vessel are disclosed. In some embodiments, the systems and methods include the following: a delivery device including a needle a space creating mechanism for creating space outside near and far walls of the vessel a suture ligator including a far wall buttress that is positioned outside the far wall of the vessel via the needle a near wall buttress that is positioned and secured along the suture ligator outside the near wall of the vessel via the needle and a plunger for positioning the near wall buttress downwardly at a position along the suture ligator so that the near wall buttress compresses the vessel but is not joined with the far wall buttress and a locking mechanism for securing the near wall buttress to the suture ligator at a position proximate to the far wall buttress thereby ligating the vessel.
