Ki Ho Kim;Jin Guk Kim;Kyoung Tae Kim;Sang iL Lee;Ki Soo Kim;Young Heui Kim;Chang Sung Han
发明人:
Ki Ho Kim,Ki Soo Kim,Young Heui Kim,Jin Guk Kim,Kyoung Tae Kim,Chang Sung Han,Sang iL Lee
申请号：
US13120818
公开号：
US08604087B2
申请日:
2009.09.25
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed is a composition for treating or preventing amyloid-related diseases including 4-O-methylhonokiol as an active ingredient. More specifically, a pharmaceutical composition including 4-O-methylhonokiol, which is effective for treating or preventing amyloid-related diseases such as Alzheimer's disease, cognitive disorder, defective memory, amyloidosis, etc. is disclosed. The inventors of the present disclosure have found out for the first time that 4-O-methylhonokiol inhibits the production of β-amyloid. It has been confirmed to be useful in treating or preventing amyloid-related diseases. Through animal tests including water maze test and passive avoidance test on mice, 4-O-methylhonokiol has been confirmed to be effective for amyloid-related diseases such as Alzheimer's disease, defective memory, cognitive disorder, and the like. It was further confirmed through acetylcholinesterase activity inhibition test using mouse brain cortex and hippocampus tissue that they are particularly effective in treating or preventing Alzheimer's disease among the amyloid-related diseases.
