there is a great need for compositions comprising FVIII that do not show any turbidity or other relevant impairment of quality like e.g. significant loss of activity before lyophilization and possess long term stability after lyophilization at the same time. As the requirements of a stable solution prior to lyophilization and a stable lyophilisate in terms of composition may differ significantly, both conditions have to be considered when developing such a stable formulation.It has now been surprisingly discovered that this can be achieved by compositions according to this invention, which comprise histidine and calcium at certain minimum concentrations.
