The instant invention is generally directed to a patient-friendly drug delivery system for targeted populations, such as pediatric and geriatric patients. Specifically, the present invention relates to a pharmaceutical composition in the form of mini-tablets. Even more specifically, the present invention relates to a pharmaceutical composition comprising a therapeutically-effective amount of melatonin in the form of mini-tablets.La presente invencion se dirige generalmente a un sistema de administracion de farmacos amigable para el paciente para poblaciones especificas, tales como pacientes pediatricos y geriatricos; especificamente, la presente invencion se refiere a una composicion farmaceutica en forma de mini-tabletas; incluso mas especificamente, la presente invencion se refiere a una composicion farmaceutica que comprende una cantidad terapeuticamente eficaz de melatonina en forma de mini-tabletas.