BERSTEIN DAVID L.,DAVID L. BERSTEIN,METCALF CHESTER A. III,CHESTER A. III METCALF,ROZAMUS LEONARD W.,LEONARD W. ROZAMUS,WANG YIHAN,YIHAN WANG
申请号：
PL371526
公开号：
PL216224B1
申请日:
2003.02.03
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
The invention concerns a method for producing a compound of the formula: by reacting rapamycin with (R)(R)P(=O)-Cl or (R)(RO)P(=O)-Cl to form the compound, wherein each occurrence of R is aryl or is an independently chosen C 1 -C 6 alkyl group optionally bearing one or more halo, -OH, alkoxyl-, alkyloxyLalkyloxyl-, haloalkyl-, hydroxyalkoxyl-, acyl-, acyloxy-, heterocyclic, aryl or heteroaryl substituents.
