您的位置: 首页 > 农业专利 > 详情页

1. Compounds directed to il-23a and TNF - α and their uses
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;MACROGENICS, INC.
发明人:
BARRETT, Rachel Rebecca,JOHNSON, Leslie S.,SINGH, Sanjaya,LAST-BARNEY, Kathleen,SHIH, Daw-Tsun,GIBLIN, Patricia,BRODEUR, Scott,NAGARAJA, Nelamangala
申请号:
PE2017000401
公开号:
PE20171139A1
申请日:
2015.09.03
申请国别(地区):
PE
年份:
2017
代理人:
摘要:
1. Refers to the first and second polypropylene compounds, in which: (a) the first polypropylene includes: (I) the light chain variable domain of the first specific immunoglobulin (VL1); (II) the heavy chain variable domain of the second immunoglobulin (VH2), specifically for the second protein target; and (III) a bisagra region, a constant heavy chain region 2 (CH2) and a constant heavy chain region 3 (CH3);Y (b) the second polyacrylonitrile includes: (1) the light chain variable domain of the second immunoglobulin (VL2) is specifically for the second target protein; (2) the heavy chain variable domain of the first immunoglobulin (VH1) is specifically for the first target protein; Among them: (1) these VL1 and VH1 are connected to form a binding site, which is connected to the first protein target; (2) these VL2 and VH2 are connected to form a binding site, which is connected to the second protein target; (3) this heavy chain constant region 2 (CH2) includes a thyroid gland at position 252, which is a treonin at the position 254 and anhydrides 256,According to Kabat EU index number; and (IV) the first proteome is tnf-alfa, the second proteome is il-23a, the second proteome is il-23a, and the second proteome is Diana tnf-alfa, wherein: (I) VL1 includes SEQ ID No.2, VH1 includes SEQ ID No.1, and this VL2 includes SEQ ID No.8. VH2 includes SEQ ID No.7; or (II) VL1 includes SEQ ID No.4 or 6; VH1 includes SEQ ID No.3 or 5; VL2 includes SEQ ID No.8; VH2 includes SEQ ID No.7; or (III) VL1 includes SEQ ID No.8; VH1 includes SEQ ID No.7; VL2 includes SEQ ID No.2,VH2 includes SEQ ID No.1; or (IV) VL1 includes SEQ ID No.8; VH1 includes SEQ ID No.7; VL2 includes SEQ ID No.4 or 6; VH2 includes SEQ ID No.3 or 5Se refiere a un compuesto que comprende un primer y segundo polipeptido, en el que: (A) dicho primer polipeptido comprende: (i) un dominio variable de cadena ligera de una primera inmunoglobulina (VL1) especifico para una primera proteina diana; (ii) un dominio variable de
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充