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Novel compounds as dual inhibitors of phosphodiesterases and histone deacetylases
专利权人:
Fundacion para la Investigacion Medica Aplicada
发明人:
CUADRADO TEJEDOR, María Del Mar,FRANCO FERNÁNDEZ, Rafael,GARCÍA OSTA, Ana María,OYARZABAL SANTAMARINA, Julen,RABAL GRACIA, Maria Obdulia
申请号:
DK14707155
公开号:
DK2961741T3
申请日:
2014.02.27
申请国别(地区):
DK
年份:
2017
代理人:
摘要:
It relates to certain compounds having a polycyclic structure and a hydroxamic acid moiety, wherein the polycyclic structure comprises at least three ring systems, wherein one ring system is a polycyclic ring system comprising from 2 to 4 rings; at least one ring is an aromatic ring; and wherein the structure comprises at least 3 nitrogen atoms and 1 oxygen atom. It also relates to a process for their preparation, as well as to pharmaceutical compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of neurological disorders coursing with a cognition deficit or impairment, or neurodegenerative diseases. wherein B1 is a radical selected from the group consisting of formula (A″), formula (B″), formula (C″), and formula (D″):
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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