DEMATTEI JOHN,LOOKER ADAM R,NEUBERT-LANGILLE BOBBIANNA,TRUDEAU MARTIN,ROEPER STEFANIE,RYAN MICHAEL P,YAP DAHRIKA MILFRED LAO,KRUEGER BRIAN R,GROOTENHUIS PETER D.J,BOTFIELD MARTYN C,ZLOKARNIK GREGOR,VA
申请号：
NZ59515310
公开号：
NZ595153A
申请日:
2010.03.19
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
The disclosure provides a process for the preparation of a substituted 4-Hydroxy-N-phenylquinoline-3-carboxamide derivative of Formula 1； comprising coupling a substituted 4-Hydroxyquinoline-3-carboxylic acid derivative of Formula 2； with an substituted aniline of Formula 3； in the presence of a coupling agent. The compounds of formula I being useful as cystic fibrosis transmembrane conductance regulators.
