A method and system of the invention generally relate to measuring ambient pressure in systems comprising incompressible fluids. Particularly, the method and system relate to monitoring pressure within body lumens. The ambient pressure may be measured by transmitting a frequency comb having non-uniform spacing between transmitted frequencies at the passive sensor and measuring the frequency response of the passive sensor. In one embodiment, a higher-order harmonic of the sensor is excited and measured to determine the ambient pressure. In another embodiment, the frequency response of frequencies in-between the transmitted frequencies are measured to determine the ambient pressure.
