MALONAMIDES AS OREXIN ANTAGONISTS.

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

LUCA GOBBI,HENNER KNUST,PARICHER MALHERBE,MATTHIAS NETTEKOVEN,EMMANUEL PINARD,OLIVIER ROCHE,MARK ROGERS-EVANS

申请号：

BRPI0808737

公开号：

BRPI0808737A2

申请日:

2008.03.05

申请国别(地区):

BR

年份:

2014

代理人:

摘要：

The present invention relates to compounds of formula I wherein Ar1, Ar2, R, R1, R2, R3 and n are as defined herein or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved like sleep disorders.

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