An antibacterial powder has a core-shell composite structure. The core-shell composite structure includes a core which is a zinc oxide particle and a shell including zinc sulfide. The shell is formed by modifying the surface of the zinc oxide particle of the core.本發明提供一種抗菌粉體,其具有芯殼層結構,該芯殼層結構包括一芯層與包覆於該芯層表面之一殼層,其中芯層為氧化鋅微粒,殼層包括硫化鋅,且殼層係由芯層氧化鋅微粒表面改質製得。