PURPOSE: PPAR alpha, gamma, and delta active materials using Dendropanax morbifera Lev. leaves are provided to prevent or treat diseases such as obesity, diabetes, hyperlipidemia, hypertension, atherosclerosis, cardiovascular diseases, metabolic diseases, cancer, and inflammation, and to be used as a main ingredient of a pharmaceutical product, a functional food, and a health food.CONSTITUTION: A method for isolating PPAR alpha, gamma, and delta active materials using Dendropanax morbifera Lev. leaves comprises: a step of extracting Dendropanax morbifera Lev. leaves with hydrous alcohol and preparing concentrate(S101) and a step for fractioning the concentrate with a non-polar solvent(S103). The PPAR alpha, gamma, and delta active materials contain a Dendropanax morbifera Lev. leaf extract and a fraction thereof. The PPAR alpha, gamma, and delta active materials further contains a pharmaceutically acceptable inactive carrier. The inactive carrier is selected from a group consisting of starch and lactose.COPYRIGHT KIPO 2013[Reference numerals] (AA) Start (BB) End (S101) Concentration step of extracting Dendropanax morbifera Lev. leaves with hydrous alcohol and preparing concentrate (S103) Fraction preparing step for fractioning the concentrate obtained from the concentration step with a non-polar solvent본 발명은 글루코스의 항상성을 조절하는 PPAR α, γ 및 δ의 활성을 증대시키는 작용이 우수하여 인슐린 저항증 및 당뇨병과 관련된 고혈당증 치료 및 예방을 위한 의약품, 기능성 식품 및 식품첨가물로 유용한 PPAR α, γ 및 δ 활성물질 및 그 추출방법에 관한 것으로, 더욱 상세하게는 황칠나무 잎을 함수알코올로 추출하여 농축액을 제조하는 농축단계 및 상기 농축단계에서 얻어진 농축액을 비극성 용매로 분획하는 분획물제조단계로 이루어지며, 이러한 추출방법을 통해 추출된 활성물질은 글루코스의 항상성을 조절하는 PPAR α, γ 및 δ의 활성을 증대시키는 탁월한 효과를 나타낸다.
