A method of treating neurological condition in a subject by administration of an extract or fraction or sub fraction thereof of Nerium species or Thevetia species is provided wherein the extract or fraction or sub fraction thereof excludes oleandrin and neriifolin. Alzheimer s disease Huntington s disease or stroke are treated by administering a therapeutically effective amount of the extract or a fraction or sub fraction thereof to a subject. The extract can be present in a pharmaceutical composition.