EVALUATION METHOD AND SCREENING METHOD FOR S1P1 RECEPTOR AGONIST

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专利权人:

发明人:

Tomohisa NINOMIYA,Satoshi YOSHIDA

申请号：

US14912827

公开号：

US20160195513A1

申请日:

2014.08.20

申请国别(地区):

US

年份:

2016

代理人:

摘要：

It has been found that a main effect (immunosuppressive activity) of an S1P1 receptor agonist correlates with the selectivity for cells expressing a combination of an S1P1 receptor with Gαi2 or Gαi3, and that an adverse effect (cardiotoxicity) of an S1P1 receptor agonist correlates with the selectivity for cells expressing a combination of an S1P1 receptor with Gαi1.

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中国工程科技知识中心

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http://www.ckcest.cn/home/