Method for producing 3, 4-disubstituted pyrrolidine derivative and production intermediate thereof
- 专利权人:
- 发明人:
- ARAYA ICHIRO,ORITA KAZUO
- 申请号：
- IN5992/CHENP/2012
- 公开号：
- IN2012CN05992A
- 申请日:
- 2012.07.06
- 申请国别(地区):
- IN
- 年份:
- 2015
- 代理人:
- 摘要：
Provided is an inexpensive and industrially advantageous method for preparing (3R,4S)-3-(N-substituted aminomethyl)-4-fluoropyrrolidine or an enantiomer thereof which can be an intermediate for producing pharmaceuticals. It relates to a method for preparing (3R,4S)-3-(N-substituted cyclopropylaminomethyl)-4-fluoropyrrolidine derivative or aits enantiomer, or their salts, comprising a step of fluorinating a 4-hydroxy-3-(N-substituted aminomethyl)pyrrolidine derivative represented by the general formula (1) or an enantiomer thereof using a sulfur tetrafluoride derivative. [In the formula (1), PG represents a protective group for the amino group, and R 1 represents a C1 to C6 alkyl group which may be substituted, or a C3 to C8 cycloalkyl group which may be substituted.]
[EP2524911A1]
- 来源网站：
- 中国工程科技知识中心
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