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ORAL DOSAGE FORM SAFEGUARDED AGAINST ABUSE CONTAINING (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)PHENOL
专利权人:
发明人:
JOHANNES BARTHOLOMAUS,HEINRICH KUGELMANN
申请号:
IN29/DELNP/2007
公开号:
IN271578B
申请日:
2007.01.02
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The present invention relates to an abuse-proofed, oral dosage form with controlled release of (1 R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, characterised in that it comprises the active ingredient and/or one or more of the pharmaceutically acceptable compounds thereof (A), at least one synthetic and/or natural polymer (C), delayed-release auxiliary substances, optionally further physiologically acceptable auxiliary substances (B) and optionally a wax (D), wherein the dosage form in each case exhibits a breaking strength of at least 500 N, preferably of at least 750 N. The dosage form contains at least one of the following abuse-preventing components (a)-(f): (a) at least one substance which irritates the nasal passages and/or pharynx, (b) at least one viscosity-increasing agent, (c) at least one antagonist for the active ingredient with potential for abuse, (d) at least one emetic, (e) at least one dye as an aversive agent, (f) at least one bitter substance.
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