A process for the preparation of 3-(hydroxymethyl)-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5h-imidazo[2,1-b][3]benzazepine an intermediate of alcaftadine or salt thereof
DEO KESHAV,DEO KESHAV,MERWADE ARVIND YEKANATHSA,MERWADE ARVIND YEKANATHSA,RAFEEQ MOHAMMAD,RAFEEQ MOHAMMAD,ROHIT KUMAR SINHA,Rohit Kumar Sinha,Chaniyara Ravi,Chaniyara Ravi
申请号：
IN3105/MUM/2013
公开号：
IN2013MU03105A
申请日:
2013.09.30
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to a process for the preparation of 3-(hydroxymethyl)-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-imidazo[2,1-b][3]benzazepine of formula II or its salt from 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-imidazo[2,1-b][3]benzazepine or its salt by using formaldehyde in presence of acetic acid, sodium acetate and water. Formula II
