Provided herein are anti depressant and anxiolytic herbal formulations including: 225-450 mg of Nyctanthes arbor-tristis, 250-550 mg Ocimum tenuiflorum, 200-450 mg Hippophae salicifolia, and optionally additives selected from minerals, vitamins, salt, filler and binder. Also provided are methods of making such formulations and methods of using such formulations for treating or improving brain function.