A device (60) for facilitating passage of a substance (72) through skin (68) on the body of a subject, comprising:a first electrode (64), adapted to be applied to the skin (68)a mechanical sensor (76), adapted to detect an indication of a contact force between the electrode (64) and the skin (68) and to generate a sensor signal responsive thereto anda control unit (66), adapted to receive the sensor signal and, responsive thereto, to drive the first electrode (64) to apply a current to the skin (68) capable of ablating stratum corneum epidermidis thereof, so as to facilitate transdermal passage of the substance (72).
