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EXCIPIENTS MODIFICATEURS DE LIBÉRATION À BASE D'AMIDON ET COMPOSITIONS PHARMACEUTIQUES DÉRIVÉES DE CEUX-CI
专利权人:
Altus Formulation Inc.
发明人:
申请号:
EP18867198.6
公开号:
EP3694557A1
申请日:
2018.10.11
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
There is provide an extended release dosage form comprising a release modifying excipient comprising high amylose starch, cross-linked hydroxypropylated amylopectin, and a pre-gelatinized common starch; wherein the release modifying excipient is substantially free of crosslinks between amylose and amylopectin and substantially free of crosslinks between amylose and amylose. It has been found that the extended release properties of conventional cross-linked high amylose starches (e.g., Contramid®) can be reproduced by intimately mixing i) cross-linked chemically modified amylopectin; ii) a high amylose, non-chemically modified starch and; iii) a pre-gelatinized common starch. Producing a release modifying excipient in this way means that no chemical cross linking between (a) amylose and amylopectin or (b) amylose and amylose has occurred - properties heretofore considered vital for Contramid® function. The release modifying excipient blends overcome problems associated with use of Contramid, and provide a flexible platform for formulation of active pharmaceutical ingredients for controlled release applications.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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