A general-purpose mobile communication device, general-purpose computer user-interface device, and other non-health-related electronic devices with cardiovascular monitoring capability. Various aspects of the present invention may comprise a general-purpose mobile communication device (e.g., a cellular telephone, portable email device, personal digital assistant, etc.) comprising a communication interface module adapted to communicate with a general-purpose communication network, and at least one module operational to acquire cardiac information from a user of the general-purpose mobile communication device. The general-purpose communication device may, for example, comprise a cardiac sensor (e.g., electrodes) disposed on the mobile communication device, which may be utilized to acquire cardiac information during use of the mobile communication device. Various aspects of the present invention may also comprise a non-health related electronic device (e.g., a general-purpose mobile communication device, general-purpose user-interface device for a general-purpose computer, gaming controller, etc.) that, during normal non-health-related utilization, acquire, analyze and/or communicate user health-related information.