The one multiple particle of Seed Hydroxyalkyl Hydrogen codeinones can be made with the Erbium-doped conjunction objects for containing sliding Elixirs With (e) the water penetration improvement Elixirs of (a) Hydroxyalkyl Hydrogen codeinones, (b) water-insoluble ammonio methacrylate copolymer, (c) plastic Elixirs, (d) Run by Squeeze System Fitness When with System.一種羥氫可待因酮多重微粒,其可以藉擠製適當地含有(a)羥氫可待因酮、(b)非水溶性甲基丙烯酸銨共聚物、(c)可塑劑、(d)潤滑劑與(e)透水性改良劑的摻合物以製造。