The present invention relates to novel antibodies and fragments that bind to a V-domain Ig Suppressor of T cell Activation (VISTA), and methods of making and using same. Methods of use include methods of treatment of cancer, including leukemias, lymphomas, solid tumors and melanomas.本發明係關於結合於T細胞活化之V域Ig抑制因子(VISTA)的新穎抗體及片段,以及其製備及使用方法。使用方法包括治療癌症之方法,其中癌症包括白血病、淋巴瘤、實體腫瘤及黑色素瘤。