2,3-Dihydrobenzo [1,4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheral and central nervous system disorders
Arto Karljalainen,Arto Tolvanen,David Din Belle,GERD WOHLFAHRT,Patrik Holm,Petteri Rummakko
申请号：
BRPI0814529
公开号：
BRPI0814529B1
申请日:
2008.07.18
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
2,3-dihydrobenzo [1,4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of diseases of the peripheral and central nervous system are the compounds of formula (i), wherein x, z, r1-r4 , as defined in the claims, exhibit alpha2c antagonistic activity and thus are useful for the treatment of diseases and conditions of the peripheral and central nervous system (snc).derivados de 2,3-dihidrobenzo[l,4]dioxin-2-ilmetil como antagonistas de alfa2c para uso no tratamento de doenças do sistema nervoso periférico e central os compostos de fórmula (i), em que x, z, r1-r4, e m são como definidos nas reivindicações, exibem atividade antagônica de alfa2c e assim são úteis para o tratamento de doenças e condições do sistema periférico e sistema nervoso central (snc).
