Marco M. Kessler;Nicholas G. Moss;Daniel P. Zimmer;Michael F. Goy;Mark G. Currie;Robert M. Solinga
发明人:
Mark G. Currie,Michael F. Goy,Marco M. Kessler,Nicholas G. Moss,Robert M. Solinga,Daniel P. Zimmer
申请号：
US13132262
公开号：
US20120028897A1
申请日:
2009.12.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods of treating fluid retention disorders with the B isomers of guanylin family peptides are described herein. UgnB, when compared to the A isomer (UgnA), exhibits a conventional sigmoidal dose-response relationship in its natriuetic activity. Further, unlike UgnA, UgnB only weakly activates the GC-C receptor. Compositions comprising purified, or mixtures containing B isomers of guanylin family peptides are described herein are therefore useful for the treatment of fluid retention disorders.
